Fabrication and Cell Culturing on Carbon Nanofibers/ Nanoparticles Reinforced Membranes for Bone-Tissue Regeneration
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서지정보
ㆍ발행기관 : 한국탄소학회
ㆍ수록지정보 : Carbon Letters / 13권 / 3호
ㆍ저자명 : XuLiangDeng, XiaoPingYang
ㆍ저자명 : XuLiangDeng, XiaoPingYang
목차
Abstract1. Introduction
2. Experimental
3. Results and Discussion
4. Conclusions
References
한국어 초록
Poly-L-lactic acid (PLLA), PLLA/hydroxyapatite (HA), PLLA/multiwalled carbon nanotubes(MWNTs)/HA, PLLA/trifluoroethanol (TFE), PLLA/gelatin, and carbon nanofibers
(CNFs)/β-tricalcium phosphate (β-TCP) composite membranes (scaffolds) were fabricated
by electrospinning and their morphologies, and mechanical properties were characterized for
use in bone tissue regeneration/guided tissue regeneration. MWNTs and HA nanoparticles
were well distributed in the membranes and the degradation characteristics were improved.
PLLA/MWNTs/HA membranes enhanced the adhesion and proliferation of periodontal ligament
cells (PDLCs) by 30% and inhibited the adhesion of gingival epithelial cells by 30%.
Osteoblast-like MG-63 cells on the randomly fiber oriented PLLA/TEF membrane showed
irregular forms, while the cells exhibited shuttle-like shapes on the parallel fiber oriented
membrane. Classical supersaturated simulated body fluids were modified by CO2 bubbling
and applied to promote the biomineralization of the PLLA/gelatin membrane; this resulted
in predictions of bone bonding bioactivity of the substrates. The β-TCP membranes exhibit
good biocompatibility, have an effect on PDLC growth comparable to that of pure CNF
membrane, and can be applied as scaffolds for bone tissue regeneration.
영어 초록
Poly-L-lactic acid (PLLA), PLLA/hydroxyapatite (HA), PLLA/multiwalled carbon nanotubes(MWNTs)/HA, PLLA/trifluoroethanol (TFE), PLLA/gelatin, and carbon nanofibers(CNFs)/β-tricalcium phosphate (β-TCP) composite membranes (scaffolds) were fabricatedby electrospinning and their morphologies, and mechanical properties were characterized foruse in bone tissue regeneration/guided tissue regeneration. MWNTs and HA nanoparticleswere well distributed in the membranes and the degradation characteristics were improved.PLLA/MWNTs/HA membranes enhanced the adhesion and proliferation of periodontal ligamentcells (PDLCs) by 30% and inhibited the adhesion of gingival epithelial cells by 30%.Osteoblast-like MG-63 cells on the randomly fiber oriented PLLA/TEF membrane showedirregular forms, while the cells exhibited shuttle-like shapes on the parallel fiber orientedmembrane. Classical supersaturated simulated body fluids were modified by CO2 bubblingand applied to promote the biomineralization of the PLLA/gelatin membrane; this resultedin predictions of bone bonding bioactivity of the substrates. The β-TCP membranes exhibitgood biocompatibility, have an effect on PDLC growth comparable to that of pure CNFmembrane, and can be applied as scaffolds for bone tissue regeneration.참고 자료
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