Implications of specific gene expression patterns in enamel knot in tooth development
(주)코리아스칼라
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- 2023.04.03
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- 2020.03
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서지정보
ㆍ발행기관 : 대한구강생물학회
ㆍ수록지정보 : International Journal of Oral Biology / 45권 / 1호
ㆍ저자명 : Tae-Young Kim, Sanjiv Neupane, Yam Prasad Aryal, Eui-Seon Lee, Ji-Youn Kim, Jo-Young Suh, Youngkyun Lee, Wern-Joo Sohn, Seo-Young An, Jung-Hong Ha, Chang-Hyeon An, Jae-Young Kim
목차
Introduction
Materials and Methods
1. 실험동물
2. 조직형태학
3. 조직절편 제자리보합법
4. 관찰 및 촬영
Results
1. 치아 발생 단계 조직형태학적 변화 및 일차 법랑질 결절의특징
2. 일차 법랑질 결절 특이적 유전자의 발현 분석
Discussion
References
영어 초록
Enamel knot (EK)—a signaling center—refers to a transient morphological structure comprising epithelial tissue. EK is believed to regulate tooth development in early organogenesis without its own cellular alterations, including proliferation and differentiation. EKs show a very simple but conserved structure and share functions with teeth of recently evolved vertebrates, suggesting conserved signaling in certain organs, such as functional teeth, through the course of evolution. In this study, we examined the expression patterns of key EK-specific genes including Dusp26 , Fat4, Meis2, Sln , and Zpld1 during mice embryogenesis. Expression patterns of these genes may reveal putative differentiation mechanisms underlying tooth morphogenesis.
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