랫드에서 백두옹과 청호의 경구투여에 의한 반복 투여독성 시험과 면역 활성 평가

서지정보

ㆍ발행기관 : 한국식품위생안전성학회 ㆍ수록지정보 : 한국식품위생안전성학회지 / 27권 / 1호
ㆍ저자명 : 안인정, 권중기, 이진석, 이성호, 박영석, 박병권, 김상기, 김병수, 조성대, 최창순, 이병희, 강병곤, 정지윤

목차

ABSTRACT
서 론
재료 및 방법
시험물질
실험동물
시험군의 구성, 투여용량 및 용량
관찰 및 검사항목
결과 및 고찰
임상증상
체중변화
사료 및 음수섭취량 변화
안과학적 검사소견
혈액학적 검사소견
혈청 생화학적 검사소견
체중에 대한 각 장기의 상대중량비
병리조직검사 소견
요 약
감사의 글
참고문헌

영어 초록

This study was designed to evaluate a repeated oral dose toxicity and immunomodulating activity of Pulsatilla koreana and Artemisiae annuae in Sprague-Dawley rats. The female rats were treated with Pulsatilla koreana and Artemisiae annuae of control group, low group (0.5 ml/kg), medium group (1 ml/kg), high group (2 ml/ kg) for distilled water, intragastrically for 4 weeks, respectively. To ensure the safety of Pulsatilla koreana and Artemisiae annuae such as the following were observed and tested. We examined the body weight, the feed intake, the clinical signs, the ophthalmological test, the hematological and the serum biochemical analysis. We also observed the histopathological changes of liver and kidney in rats. Hematological results were the increase of neutrophils, lymphocytes and monocytes in the high dose group of Pulsatilla koreana. The increase immune cells in the high dose group of Pulsatilla koreana might immunomodulating activity. No significant differences in body weight, feed intake, serum biochemical analysis and histopathological between control and fed group were found. In conclusion, Pulsatilla koreana and Artemisiae annuae is physiologically safe and improve immunomodulating activity.

참고 자료

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