Sudden cardiac death as a naturally-occurring ventricular hypertrophy in Macaca fascicularis
(주)코리아스칼라
- 최초 등록일
- 2023.06.05
- 최종 저작일
- 2021.09
- 5페이지/ 어도비 PDF
- 가격 4,000원
* 본 문서는 배포용으로 복사 및 편집이 불가합니다.
서지정보
ㆍ발행기관 : 충북대학교 동물의학연구소
ㆍ수록지정보 : Journal of Biomedical and Translational Research / 22권 / 3호
ㆍ저자명 : Hyeon-Gu Yeo, Junghyung Park, Hyun Kuk Kim, Joo Myung Lee, Bon-Sang Koo, Jeong-Hee An, Chang-Yeop Jeon, You Jung An, Won Seok Choi, Sung-Hyun Park, Jincheol Seo, Jinyoung Won, Keonwoo Kim, Jiyeon Cho, Yu Gyeong Kim, Minji Kim, Jung Bae Seong, Jae-Won Huh, Sung Soo Kim, Youngjeon Lee, Kyung Seob Lim
목차
Abstract
INTRODUCTION
CASE REPORT
DISCUSSION
REFERENCES
영어 초록
Naturally occurring left ventricular hyperplasia is a rare but lethal disease. There are very few reports of this cardiac disease in captive nonhuman primates. In a colony of Macaca mulatta (Rhesus monkey) at California National Primate Research Center, a large number of rhesus macaques were diagnosed by autopsy with naturally occurring left ventricular hypertrophy without obvious underlying diseases over a 22-year period. The confirmatory diagnosis of ventricular hypertrophy was based on findings of notable left ventricular concentric hypertrophy with reduced left ventricular lumen, which is very similar to human ventricular hypertrophy cases. This report discusses an 11-year-old Macaca fascicularis monkey (Cynomolgus monkey, crab-eating macaque), weighing 2.95 kg, that was presented for enrollment in a pharmacokinetic (PK) study. During the PK experiment, the monkey died following a sudden decrease in percutaneous oxygen saturation and heart rate. Gross and histological examinations of the heart were performed. On gross pathology, the left ventricular wall was thickened, and the chamber lumen was reduced. In histopathological examination using hematoxylin- eosin and Masson-trichrome stains, fibrosis and myocyte disarray were not observed, but an increased cell density, compared to the normal heart, was confirmed. The autopsy results confirmed left ventricular hyperplasia as the major cause of death.
참고 자료
없음
"Journal of Biomedical and Translational Research"의 다른 논문