Lactobacillus plantarum HY7712로 발효한 야채 발효물의 혈중 콜레스테롤 저하효과

서지정보

ㆍ발행기관 : 한국유산균학회 ㆍ수록지정보 : Current Topic in Lactic Acid Bacteria and Probiotics / 2권 / 2호
ㆍ저자명 : 이명희, 윤홍섭, 최일동, 정지웅, 김성환, 라제현, 구형근, 김태열, 심재헌, 허철성, 안영태

목차

Abstract
서 론
재료 및 방법
유산균
실험동물 및 실험식이
혈액 및 간조직 내 항산화 활성 분석
혈액 및 간조직 내 지질분석
분변 담즙산 분석
통계분석
결과 및 고찰
체중 증가량, 식이섭취량 및 식이효율(FER)
혈액과 간에서의 항산화 활성 변화
혈중 및 간지질 변화
분변내 담즙산 농도 변화
요 약
참고문헌

영어 초록

The cholesterol lowering effect of vegetables fermented by Lactobacillus plantarum HY7712 was evaluated in rats fed high fat/high cholesterol diet. SD Rats were randomly divided into three groups, then fed a normal diet (ND), a highfat high-cholesterol diet (HFCD), or HFCD and vegetables fermented by HY7712 (VFLAB) for 5 weeks, and the biomarkers in the blood, liver, and feces of rats were measured. Antioxidant status such as SOD, CAT, GSH/GSSG, and MDA was significantly deteriorated in HFCD compared with ND (p<0.01) but was improved in VFLAB to the level of ND. In addition, the level of MDA in VFLAB was significantly decreased in comparison with HFCD (p<0.05). Total cholesterol, LDLcholesterol, and atherogenic index (AI) were significantly increased in HFCD, but significantly decreased in VFLAB (p<0.05). In addition, administration of a HFCD diet increased the fecal bile acid in rats and the concentration of fecal bile acid was higher in VFLAB than in HFCD. In conclusion, the vegetables fermented by L. plantarum HY7712 improved antioxidant status and hypercholesterolemia induced by HFCD diet, which may be due to the synergic effect of lactic acid bacteria and fermented vegetables.

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