Oct4-Induced Pluripotency in Adult Neural Stem Cell

목차

1. History
2. What they did and hypothesized
3. Results
4. Discussion
5. Conclusion
6. References

본문내용

History
For centuries, embryologists have been intrigued by the distinction between germ cells and soma.
One way of establishing a distinction between germline and soma is to determine the regulatory factors expressed in both the pluripotent cells and stem cells of the germ cell lineage but not in somatic cells
From the beginning, based on its expression profile, the transcription factor Oct4 was considered to be a key regulator during mouse embryogenesis.

Oct4 is expressed in the pluripotent cells of an embryo, as well as in the GC lineage.
The early developmental phenotype suggests that Oct4 is part of a regulatory system that maintains pluripotency.
Precise level of Oct4 is required to maintain pluripotency in ES cells.
-> Loss of Oct 4 results in diffrentiation into trophectodermal cells, and over-expression of Oct 4 in ESC leads to differentiate mesodermal and endodermal fates.

<중 략>

1F iPS Can Be Differentiated into Three Germ Layes including NSCs, Cardiomyocytes, and GCs In Vitro

immunocytochemical staining of 1F NSC indicates that 1F NSC can differentiate into various neural cells such as neurons(Tuj1), oligodendrocytes(O4), and astrocytes

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