deciphering human macrophage development at single-cell resolution 논문 리뷰 및 대본(슬라이드노트)

소개글

"deciphering human macrophage development at single-cell resolution 논문 리뷰 및 대본(슬라이드노트)"에 대한 내용입니다.

목차

1. Main

2. Method

3. Result
1) scRNA-seq of human embryo haematopoiesis
2) YSMP development in embryonic liver
3) Two waves of yolk sac-derived embryonic TRMs
4) Human microglia origin and specification

4. Discussion

본문내용

Much of our current knowledge of embryonic haematopoiesis is based on findings in animal models such as mice or zebrafish.
The characterization of these cells in humans has so far been restricted to either microscopic observations or explant experiments.

We have identified two distinct HSC-independent waves of macrophages in humans that correspond to those seen in mice.

This is especially important in the clinical context, as macrophages are essential regulators of tissue development and homeostasis, and understanding their functions and developmental pathways is key to the diagnosis and treatment of pathologies caused by their dysregulation.

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