확산형 위암의 게놈 프로파일 분석 (영문) Genomic profile analysis of diffuse-type gastric cancers

소개글

"확산형 위암의 게놈 프로파일 분석 (영문) Genomic profile analysis of diffuse-type gastric cancers"에 대한 내용입니다.

목차

1. Introduction
2. Abstract
3. Materials & Methods
4. Results
5. Conclusions
6. Reference

본문내용

- Patients and specimen collection
- Nucleic acid preparation
- Whole genome sequencing
- Exome sequencing
- Read alignment and variation detection
- SNP and small insertion/deletion analysis and somatic mutation filtering
- Mutation rate calculation
- Sanger sequencing
- Annotation of variations
- Driver gene prediction
- Purity calculation
- Identification of copy number variation regions
- Identification of structural variants (SVs) and gene fusions
- Structure prediction of CDH1

참고 자료

Lee YS, Cho YS, Lee GK, Lee S, Kim YW, Jho S, Kim HM, Hong SH, Hwang JA, Kim SY, Hong D, Choi IJ, Kim BC, Kim BC, Kim CH, Choi H, Kim Y, Kim KW, Kong G, Kim HL, Bhak J, Lee SH, Lee JS.
Genomic profile analysis of diffuse-type gastric cancers.
Genome Biol. 2014 Apr 1;15(4):R55.