동물에서 Amputational Injury 회복을 위한 Blastema의 분화

서지정보

ㆍ발행기관 : 강원대학교 동물자원공동연구소 ㆍ수록지정보 : 동물자원연구 / 22권 / 2호
ㆍ저자명 : 수프리야 시와니, 왕명현, 나레시 쿠마 싱

목차

ABSTRACT Introduction What is regeneration and wound healing? Dedifferentiation during wound healing What is blastema and how it can be obtained in non regenerating tissues Regeneration physiology and other biological processes Nerve-derived signals Signals regulating morphogenesis Wnt expression and regeneration polarity Conclusion References

영어 초록

Several vertebrate species are able to epimorphically regenerate tissue of appendages or whole appendages such as fingertips, limbs, fins, tails, antlers, and ear tissue via the formation of a blastema of proliferating cells. For structure such as mammalian ear tissue and fingertips and antlers, the origin of the cells for regeneration is uncertain, but in others, such as fish fin regeneration and amphibian limb and tail regeneration, studies revealed that the blastema is formed by the dedifferentiation of mature cells local to the region of injury. Moreover, regeneration requires specification of the identity of new tissues to be made either in lower or higher vertebrates. Whether this process relies only on intrinsic regulative properties of regenerating tissues or whether wound signaling provides input into tissue repatterning is not known. In this review, authors have made efforts to put emphasis on signaling events, importance of polarity during regeneration and put forth how the limitations of regeneration could be overcome in higher vertebrates such as animals and humans.

참고 자료

없음