Genotoxicity of Zizyphi Spinosi Semen in Bacterial Reverse Mutation (Ames) Test, Chromosomal Aberration and Micronucleus Test in Mice
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- 2023.04.05
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서지정보
ㆍ발행기관 : 한국식품위생안전성학회
ㆍ수록지정보 : 한국식품위생안전성학회지 / 27권 / 2호
ㆍ저자명 : Mei-Shu Zhang, InSeok Bang, ChangSu Kang, Cheol Beom Park
목차
ABSTRACT
Introduction
Materials and Methods
Chemicals
Plant material
Bacterial strains and CHL cells and S9
Bacterial reverse mutation (Ames) test
Chromosomal aberration test
Micronucleus test
Results
Bacterial reverse mutation (Ames) test
Chromosomal aberration test
Micronucleus test
Discussion
Acknowledgement
References
영어 초록
Zizyphi spinosi semen (Z. spinosi) has been used in traditional Chinese medicine for the treatment of rheumatoid arthritis and wounds. However, toxicity in high doses was often observed due to the presence of alkaloids. This study was conducted to investigate the potential genotoxicity of Z. spinosi in vitro and in vivo. This was examined by the Bacterial reverse mutation (Ames) test using Salmonella typhimurium TA98, TA100, TA1535, TA1537 and Escherichia coli WP2uvrA, Chromosomal aberration was investigated using Chinese hamster lung cells and the micronucleus test using mice. Z. Spinosi did not induce mutagenicity in the Ames test, and it did not produce chromosomal aberration in Chinese hamster lung cells with and without metabolic activation, nor in the micronucleated polychromatic erythrocytes in the bone marrow cells in mice. Based on these results, it is concluded that Z. spinosi does not have mutagenic potential under the conditions examined in each study.
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