국화로부터 추출한 천연염료에 대한 급성경구독성 및 피부자극성 시험에 대한 연구

서지정보

ㆍ발행기관 : 한국식품위생안전성학회 ㆍ수록지정보 : 한국식품위생안전성학회지 / 27권 / 2호
ㆍ저자명 : 권중기, 안인정, 이진석, 김혜리, 박하승, 김동찬, 최병준, 이규민, 박용진, 정지윤

목차

ABSTRACT
서 론
재료 및 방법
시험물질
실험동물 및 사육환경
시험군의 구성, 투여용량, 조제 및 투여
급성경구독성시험
피부자극성평가
통계학적 분석
결과 및 고찰
급성경구독성
피부자극성
감사의 글
요 약
참고문헌

영어 초록

This study was designed to evaluate to acute oral toxicity and skin irritation of Chrysanthemum dye in Sprague-Dawley (SD) rats. SD rats were orally treated with Chrysanthemum dye at a dose of 0, 1 and 2 ml/kg body weight. After oral administration, the rats were observed for 14days. In primary skin irritation test, SD rats were dermally treated with Chrysanthemum dye and observed for 3 days. To ensure the safety of Chrysanthemum dye such as the following were observed and tested. We examined the body weight, the feed intake, the clinical signs, the ophthalmological test, the histopathological test, the mortality and skin irritation. As a result, no significant differences were found in body weight, feed intake and histopathological test between control and Chrysanthemum dye treated group. In the result of skin irritation test, Chrysanthemum dye did not induce erythema and edema after topical application. Primary irritation index was “0” in the test. Therefore, it is suggested that Chrysanthemum dye has no effect on acute toxicity and side effect in SD rats and is non-irritant material based on the score “0” of primary irritation index.

참고 자료

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